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Documentos clave

SRP0473

BRDT (22-138) GST tag human

Name: BRDT (22-138) GST tag human
Brand: SIGMA

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:

BRD6, CT9, bromodomain, testis-specific

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

40.7 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_207189

UniProt accession no.

Q58F21

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRDT(676)

General description

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9 (GenBank Accession No. NM_207189) amino-acids 22 – 138 with N-terminal GST-tag, MW = 40.7 kDa, expressed in an E. coli expression system.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

3110820224

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The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation.

Enyuan Shang et al.

Development (Cambridge, England), 134(19), 3507-3515 (2007-08-31)

Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling. Its expression is restricted to the germ line, specifically to pachytene and diplotene spermatocytes

The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background.

Binyamin D Berkovits et al.

Developmental biology, 360(2), 358-368 (2011-10-25)

Mice homozygous for a mutation (Brdt(∆BD1/∆BD1)) lacking the first bromodomain of Brdt, a testis-specific member of the BET family of double-bromodomain containing proteins, are sterile and exhibit profound defects in chromatin remodeling during spermiogenesis. We have now observed that a

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