SML3507

Hirsutine

≥98% (HPLC)

• Sinónimos: (αE,​2S,​3R,​12bR)​-3-​Ethyl-​1,​2,​3,​4,​6,​7,​12,​12b-​octahydro-​α-​(methoxymethylene)​-indolo[2,​3-​a]​quinolizine-​2-​acetic acid methyl ester, (E)-16,17-Didehydro-17-methoxy-17,18-seco-3-beta-yohimban-16-carboxylic acid methyl ester
• Fórmula empírica (notación de Hill): C₂₂H₂₈N₂O₃
• Número de CAS: 7729-23-9
• Peso molecular: 368.47
• MDL number: MFCD01750089
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: CC[C@@]1([H])CN(CCC2=C3NC4=C2C=CC=C4)[C@]3([H])C[C@]1([H])/C(C(OC)=O)=C\OC
• InChI: 1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17-,20+/m0/s1
• InChI key: NMLUOJBSAYAYEM-AZQGJTAVSA-N

Descripción

Biochem/physiol Actions

Hirsutine is a brain penetrant alkaloid from Uncaria rhynchophylla that exhibit anti-cancer, cardioprotective, anti-hypertensive, and anti-arrhythmic activities. It appears that hirsutine induces apoptosis in lung cancer cells through opening of mitochondrial permeability transition pore (mPTP). Hirsutine exhibit potent anti-dengue virus activity.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable