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Documentos

SML2896

Sigma-Aldrich

ONO-2506

≥98% (HPLC)

Sinónimos:

(-)-(2R)-2-Propyloctanoic acid, (2R)-2-Propyloctanoic acid, (R)-(-)-2-Propyloctanoic acid, (R)-2-Propyloctanoic acid, Arundic acid, ONO 2506, ONO2506

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About This Item

Fórmula empírica (notación de Hill):
C11H22O2
Número de CAS:
185517-21-9
Peso molecular:
186.29
MDL number:
MFCD08458423
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

oil

color

colorless to yellow

storage temp.

−20°C

InChI

1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1

InChI key

YCYMCMYLORLIJX-SNVBAGLBSA-N

Biochem/physiol Actions

ONO-2506 (arundic acid; (R)-2-propyloctanoic acid) is an inhibitory astrocytes-modulating agent that exerts glioprotective effects against amyloid-β-peptide (Aβ)-induced glial death in astrocyte cultures (50 μM ONO-2506 against 200 μM Aβ25-35, 24 hr; 1321N1 astrocytes) by decreasing both the intracellular and extracellular S100B levels. Blockade of astrocytic activation by ONO-2506 in vivo is shown to offer therapeutic efficacy in animal models of normal tension glaucoma (10 mg/kg po. mice), spinal cord injury (20 mg/kg/d ip or iv rats), brain seizure, ischemic stroke (10 mg/kg/d ip or iv rats), and Parkinson′s disease (30 mg/kg ip mice).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Isato Fukushi et al.
Respiratory physiology & neurobiology, 226, 24-29 (2015-11-26)
Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles
Mojtaba Keshavarz et al.
Iranian journal of basic medical sciences, 22(5), 557-562 (2019-06-21)
Valproic and arundic acids are astrocytes-modulating agents with potential effects in the treatment of Alzheimer's disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective
Narito Tateishi et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 22(6), 723-734 (2002-06-05)
A novel agent, (R)-(-)-2-propyloctanoic acid (ONO-2506), has a unique property in that it modulates functions of activated cultured astrocytes, including pronounced inhibition of S-100beta synthesis. The present study examined whether administration of this agent would mitigate the delayed expansion of
C Mari et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 76, 41-51 (2019-06-17)
Perinatal hypoxia-ischemia (HI) is one of the main causes of mortality and chronic neurological morbidity in infants and children. Astrocytes play a key role in HI progression, becoming reactive in response to the injury, releasing S100 calcium binding protein B
M Yanagisawa et al.
Cell death & disease, 6, e1693-e1693 (2015-03-20)
Glaucoma is the second leading cause of blindness worldwide and is characterized by gradual visual impairment owing to progressive loss of retinal ganglion cells (RGCs) and their axons. Glutamate excitotoxicity has been implicated as a mechanism of RGC death in
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