SML2352

Aramchol

≥98% (HPLC)

• Sinónimos: (3β,5β,7α12α)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid, 3β-arachidyl-amido, 7α-12α-dihydroxy, 5β-cholan-24-oic acid, Arachidyl amido cholanoic acid, C20-FABAC
• Fórmula empírica (notación de Hill): C₄₄H₇₉NO₅
• Número de CAS: 246529-22-6
• Peso molecular: 702.10
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CCCCCCCCCCCCCCCCCCCC(N[C@@H]1C[C@](C[C@@H](O)[C@]2([H])[C@]3([H])C[C@H](O)[C@@]4(C)[C@@]2([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])[C@]3(C)CC1)=O

Descripción

Biochem/physiol Actions

Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer that has the potential to prevent and dissolves cholesterol gallstones in inbred mice and in human gallbladder bile ex vivo.

Aramchol is a bile salt fatty acid conjugate (BAFAC) of arachidic acid and cholic acid. It has been shown to reduce liver fat by a dual mechanism of action. It inhibits the activity of liver stearoyl coenzyme A desaturase 1 (SCD1), decreasing the synthesis of fatty acids. In addition, it activates cholesterol efflux by stimulating the adenosine triphosphate–binding cassette transporter A1 (ABCA1). Aramchol has been investigated for treatment for nonalcoholic steatohepatitis, or NASH.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable