SML2235

CL075

≥98% (HPLC)

• Sinónimos: 2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002
• Fórmula empírica (notación de Hill): C₁₃H₁₃N₃S
• Número de CAS: 256922-53-9
• Peso molecular: 243.33
• MDL number: MFCD09998898
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(nc1CCC)c(nc3c2cccc3)N
• InChI: 1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
• InChI key: NFYMGJSUKCDVJR-UHFFFAOYSA-N

Descripción

Application

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.

Biochem/physiol Actions

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.

CL075 is a thiazoloquinolone derivative. It might influence tumor development.

Toll-like receptor-8 (TLR-8) agonist

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable