Saltar al contenido
MilliporeSigma
Todas las fotos(1)

Key Documents

Otros documentos

SML1893

Sigma-Aldrich

RO5256390

≥98% (HPLC)

Sinónimos:

(S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C13H18N2O
Número de CAS:
1043495-96-0
Peso molecular:
218.29
MDL number:
MFCD28405494
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 14 to 19°, c = 1 in methanol

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC[C@@H](C[C@H]1COC(N)=N1)C2=CC=CC=C2

InChI

1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1

InChI key

IXDKFUBXESWHSL-JQWIXIFHSA-N

Biochem/physiol Actions

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaine′s reinforcng effects, and blocks binge-eating disorder.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Vincent M Lam et al.
European journal of pharmacology, 763(Pt B), 136-142 (2015-06-21)
Trace-amines (TAs) are endogenous amines that are implicated in several physiological processes including modulation of aminergic neurotransmission. These compounds exert their effect by activating a class of G protein-coupled receptors termed Trace-Amine Associated Receptors (TAARs), where TAAR1 is the only
Antonio Ferragud et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(7), 1458-1470 (2016-11-03)
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of obesity and eating disorders, as well as of the recently proposed disorder of food addiction. Trace amine-associated receptor 1 (TAAR1) is a highly conserved G-protein-coupled
F G Revel et al.
Molecular psychiatry, 18(5), 543-556 (2012-05-30)
Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico