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SML1362

Sigma-Aldrich

L755507

≥98% (HPLC)

Sinónimos:

4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide, L-755,507

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About This Item

Fórmula empírica (notación de Hill):
C30H40N4O6S
Número de CAS:
159182-43-1
Peso molecular:
584.73
UNSPSC Code:
12352200
PubChem Substance ID:
329825817
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=C(OC[C@@H](O)CNCCC2=CC=C(NS(C3=CC=C(NC(NCCCCCC)=O)C=C3)(=O)=O)C=C2)C=C1

InChI

1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1

InChI key

NYYJKMXNVNFOFQ-MHZLTWQESA-N

General description

L755507 is a derivative of 4-acylaminobenzenesulfonamide.

Application

L755507 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Biochem/physiol Actions

L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.
L755507 is a potent β3-adrenergic receptor partial agonist.
L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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E R Parmee et al.
Bioorganic & medicinal chemistry letters, 8(9), 1107-1112 (1999-01-01)
A study of 4-acylaminobenzenesulfonamides in a cloned human beta 3 adrenergic receptor assay resulted in the discovery of n-hexylurea, L-755,507 (22). This 0.43 nM beta 3 agonist, which is > 440-fold selective over both beta 1 and beta 2 binding
Tools to study β 3-adrenoceptors.
Vrydag W and Michel M C
Naunyn-Schmiedeberg'S Archives of Pharmacology, 374(5-6), 385-398 (2007)
Dana S Hutchinson et al.
British journal of pharmacology, 135(8), 1903-1914 (2002-04-18)
1. This study characterizes the mouse beta(3a)-adrenoceptor (AR) and the splice variant of the beta(3)-AR (beta(3b)-AR) expressed in Chinese hamster ovary cells (CHO-K1). 2. Stable clones with high (approximately 1200), medium (approximately 500) or low receptor expression (approximately 100 fmol
Masaaki Sato et al.
Molecular pharmacology, 74(5), 1417-1428 (2008-08-08)
This study identifies signaling pathways activated by the beta(2)-/beta(3)-adrenoceptor (AR) agonist zinterol, the selective beta(3)-AR agonist L755507, and the selective beta(3)-AR antagonist L748337 in CHO-K1 cells expressing human beta(3)-adrenoceptors. Zinterol and L755507 caused a robust concentration-dependent increase in cAMP accumulation
Chen Yu et al.
Cell stem cell, 16(2), 142-147 (2015-02-07)
The bacterial CRISPR-Cas9 system has emerged as an effective tool for sequence-specific gene knockout through non-homologous end joining (NHEJ), but it remains inefficient for precise editing of genome sequences. Here we develop a reporter-based screening approach for high-throughput identification of
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Small Molecule CRISPR Enhancers

The CRISPR-Cas9 system is an RNA-guided genome-editing tool that provides researchers a simple, easy, and quick way to modify the genomes of various organisms.

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