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Key Documents

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SML1124

Sigma-Aldrich

CPCCOEt

≥98% (HPLC)

Sinónimos:

7-Hydroxyiminocyclopropan[b]chromen-1α-carboxylic acid ethyl ester

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About This Item

Fórmula empírica (notación de Hill):
C13H13NO4
Número de CAS:
179067-99-3
Peso molecular:
247.25
MDL number:
MFCD00947859
UNSPSC Code:
12352200
PubChem Substance ID:
329825663
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OCC)C(C1)(OC2=C/3C=CC=C2)C1C3=N/O

InChI

1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-

InChI key

FXCTZFMSAHZQTR-KAMYIIQDSA-N

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Biochem/physiol Actions

CPCCOEt is a selective non-competitive metabotropic glutamate receptor mGluR1 antagonist with no agonist or antagonist activity at mGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The Journal of pharmacology and experimental therapeutics, 367(1), 59-70 (2018-07-29)
Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of reports of aberrant
Valerie L Hedges et al.
Endocrinology, 159(3), 1328-1338 (2018-01-31)
Estrogens affect cerebellar activity and cerebellum-based behaviors. Within the adult rodent cerebellum, the best-characterized action of estradiol is to enhance glutamatergic signaling. However, the mechanisms by which estradiol promotes glutamatergic neurotransmission remain unknown. Within the mouse cerebellum, we found that
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The Journal of physiology, 595(11), 3483-3495 (2017-02-18)
Spontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (afferent) auditory system before hearing begins. Just before the onset of hearing, descending (efferent) input from cholinergic neurons originating in the brainstem inhibit inner hair cell
Zhiwen Zeng et al.
Oncotarget, 8(39), 65313-65328 (2017-10-17)
Impairment of insulin-like growth factor I (IGF-I) signaling plays an important role in the development of neurodegeneration. In the present study, we investigated the effect of H
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