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SML1075

Sigma-Aldrich

Atglistatin

≥98% (HPLC), powder, adipose triglyceride lipase inhibitor

Sinónimos:

3-(4′-(Dimethylamino)-[1,1′-biphenyl]-3-yl)-1,1-dimethylurea

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About This Item

Fórmula empírica (notación de Hill):
C17H21N3O
Número de CAS:
1469924-27-3
Peso molecular:
283.37
MDL number:
MFCD28009494
UNSPSC Code:
12352200
PubChem Substance ID:
329825457
NACRES:
NA.77

Nombre del producto

Atglistatin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O

InChI

1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)

InChI key

AWOPBSAJHCUSAS-UHFFFAOYSA-N

Application

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

Biochem/physiol Actions

Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

Other Notes

Produced under the license of University of Graz/Graz University of Technolog

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
116M4703V
104M4719V

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