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Key Documents

SML0884

Sigma-Aldrich

bpV(HOpic)

≥90% V basis

Sinónimos:

Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K2[VO(O2)2C6H4NO3]

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About This Item

Fórmula empírica (notación de Hill):
K2VOO2O2C6H4NO3
Número de CAS:
722494-26-0
Peso molecular:
347.24
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥90% V basis

form

powder

storage condition

desiccated
protect from light

color

faintly yellow to dark yellow

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

Application

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.

Biochem/physiol Actions

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.

Other Notes

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Park J, et al.
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Thomas Theis et al.
Molecular neurobiology, 55(10), 8203-8215 (2018-03-10)
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