SMB01018

Cynaropicrin

≥90% (LC/MS-ELSD)

• Fórmula empírica (notación de Hill): C₁₉H₂₂O₆
• Número de CAS: 35730-78-0
• Peso molecular: 346.37
• MDL number: MFCD31614147
• UNSPSC Code: 12352205

Propiedades

• assay: ≥90% (LC/MS-ELSD)
• form: solid
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• InChI: 1S/C19H22O6/c1-8-5-14(24-18(22)9(2)7-20)16-11(4)19(23)25-17(16)15-10(3)13(21)6-12(8)15/h12-17,20-21H,1-7H2/t12-,13-,14-,15-,16+,17+/m0/s1
• InChI key: KHSCYOFDKADJDJ-NQLMQOPMSA-N

Descripción

General description

Cynaropicrin is a sesquiterpene lactone, a bioactive natural compound commonly derived from plants such as Cynara scolymus, Pleiotaxis rugosa, Pseudostifftia kingii, Blumea eriantha, and Scopolia atropoides. Current research indicates that this plant metabolite is an inhibitor and may possess diverse biological activities, including anti-inflammatory, antineoplastic, antispasmodic, anti-hyperlipidemic, anti-trypanosomal, anti-malarial, and antiviral properties.

Application

Cynaropicrin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, making it a potential candidate for preventing UVB-induced photoaging. Additionally, it exhibits pro-apoptotic activity, suggesting its potential as an anticancer agent against certain leukocyte cancer cells such as lymphoma or leukemia. Cynaropicrin has demonstrated in vivo activity against Trypanosoma brucei and exhibits immunomodulatory effects by influencing cytokine release and nitric oxide production while also displaying immunosuppressive properties. Moreover, it has anti-inflammatory effects by inhibiting the production of inflammatory mediators and lymphocyte proliferation, which is achieved through conjugation with sulphydryl groups of target protein(s).

Features and Benefits

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Other Notes

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Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable