Saltar al contenido
MilliporeSigma
Todas las fotos(1)

Key Documents

SMB00915

Sigma-Aldrich

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)

≥95% (HPLC)

Sinónimos:

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C25H40O5
Número de CAS:
27240-87-5
Peso molecular:
420.58
UNSPSC Code:
41141802
NACRES:
NA.25

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

mp

153.5—154.5 °C

solubility

chloroform: 20 mg/mL, colorless to light yellow

storage temp.

2-8°C

General description

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.
Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.

Application

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Irina Alimov et al.
The Journal of biological chemistry, 294(10), 3359-3366 (2019-01-17)
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor affecting both host

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico