SAB5702163

Anti-STAT6 Antibody, clone 4G7J8, Rabbit Monoclonal

• Sinónimos: D12S1644,IL-4-STAT,STAT6B,STAT6C,STAT6
• UNSPSC Code: 12352203

Propiedades

• biological source: rabbit
• Quality Level: 100
• material: colorless
• clone: 4G7J8, monoclonal
• form: liquid
• mol wt: 100 kDa
• species reactivity: mouse, mouse
• concentration: 0.8 mg/mL
• technique(s): immunofluorescence: 1:50 - 1:200; immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000
• color: colorless
• isotype: IgG
• UniProt accession no.: P42226
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... STAT6(6778)

Descripción

General description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Immunogen

A synthesized peptide derived from human STAT6

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IF/ICC, IP

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1