SAB5700429

Anti-Phospho-BCR-Y177 antibody produced in rabbit

• Sinónimos: ALL, BCR, BCR1, CML, D22S11, D22S662, PHL
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 137; 142
• species reactivity: mouse, human
• concentration: 2.66 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P11274
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr177)
• Gene Information: human ... BCR(613)

Descripción

General description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen

A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable