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Key Documents

SAB4504006

Sigma-Aldrich

Anti-phospho-VEGFR1 (pTyr1333) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 150 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P17948

UniProt accession no.

P17948

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr1333)

Gene Information

human ... FLT1(2321)

General description

Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor or vasculotropin. It is a 46kDa homodimeric peptide growth factor. This gene is located on human chromosome 13q12.

Immunogen

The antiserum was produced against synthesized peptide derived from human VEGFR1 around the phosphorylation site of Tyr1333.

Immunogen Range: 1289-1338

Application

Anti-phospho-VEGFR1 (pTyr1333) antibody has been used in immunostaining.

Biochem/physiol Actions

Vascular endothelial growth factor (VEGF) activates endothelial cell growth in vitro and angiogenesis in vivo by binding to endothelial cells. This protein participates in endothelial proliferation, regulation of vascular permeability and thrombogenicity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1
Troncoso F, et al.
PLoS ONE (2017)
Maryam Farzaneh Behelgardi et al.
Scientific reports, 8(1), 17924-17924 (2018-12-19)
Interfering with interactions of vascular endothelial growth factors (VEGFs) with their receptors (VEGFRs) effectively inhibits angiogenesis and tumor growth. We designed an antagonist peptide of VEGF-A and VEGF-B reproducing two discontinuous receptor binding regions of VEGF-B (loop 1 and loop3)
The genetic differences between gallbladder and bile duct cancer cell lines
Saito S, et al.
Oncology Reports, 16(5), 949-956 (2006)
VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease
Ganta VC, et al.
Circulation Research, 120(2), 282-295 (2017)
Vijay Chaitanya Ganta et al.
Circulation research, 120(2), 282-295 (2016-12-16)
Atherosclerotic-arterial occlusions decrease tissue perfusion causing ischemia to lower limbs in patients with peripheral arterial disease (PAD). Ischemia in muscle induces an angiogenic response, but the magnitude of this response is frequently inadequate to meet tissue perfusion requirements. Alternate splicing

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