SAB4501977

Anti-NF1 antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Neurofibromatosis-related protein NF-1, Neurofibromin
• MDL number: MFCD02264160
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 319 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI accession no.: P21359
• UniProt accession no.: P21359
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NF1(4763)

Descripción

General description

Anti-NF1 Antibody detects endogenous levels of total NF1 protein.

NF1 (neurofibromin 1) gene is mapped to human chromosome 17q11.2. The protein encoded contains more than 2800 amino acids.

Immunogen

The antiserum was produced against synthesized peptide derived from human NF1.

Immunogen Range: 1551-1600

Biochem/physiol Actions

NF1 (neurofibromin 1) is a tumor suppressor gene and negatively regulates RAS (proto-oncogene, GTPase). Mutation in NF1 is strongly associated with the pathogenesis of melanoma and also causes neurofibromatosis type 1. Loss of NF1 allele results in benign neurofibromas in nonmyelinating Schwann cell and is associated with desmoplastic melanoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable