SAB4500412

Anti-COX41 antibody produced in rabbit

affinity isolated antibody

• Sinónimos: COX IV-1, COX4, COXIV, cytochrome c oxidase polypeptide IV
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 19 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P13073
• UniProt accession no.: P13073
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... COX4I1(1327)

Descripción

General description

Anti-COX41 Antibody detects endogenous levels of total COX41 protein.

COX41 (cytochrome c oxidase subunit 4I1) is located on human chromosome 16q24. COX4NB (COX4 neighbour) and COX4I1 (COX4 isoform 1) belongs to the cytochrome C oxidase subunit IV (COX4) family.

Immunogen

The antiserum was produced against synthesized peptide derived from human COX41.

Immunogen Range: 11-60

Biochem/physiol Actions

COX4 isoform 1 (COX4-1) (COX4-1) may play an important role in glioma chemoresistance. It regulates the upregulation of BMI1 (polycomb complex protein BMI1). It is necessary for the multiplication of GBM (glioblastoma multiforme). In cells, expression of COX4-1 is necessary to maintain the stability of mitochondria and ROS (reactive oxygen species) homeostasis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable