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Key Documents

SAB4300084

Sigma-Aldrich

Anti-phospho-RPS6KA1 (pThr348) antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-HU-1 antibody produced in rabbit, Anti-MAPKAPK1A antibody produced in rabbit, Anti-RSK antibody produced in rabbit, Anti-RSK1 antibody produced in rabbit, Anti-ribosomal protein S6 kinase, 90kDa, polypeptide 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD00676462
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~90 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(S-R-TP-P-R)

NCBI accession no.

NP_001006666.1

UniProt accession no.

Q15418

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr348)

Gene Information

human ... RPS6KA1(6195)

Immunogen

Peptide sequence around phosphorylation site of threonine 348 (S-R-T(p)-P-R), according to the protein RPS6KA1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Rong-Yu Liu et al.
Scientific reports, 10(1), 608-608 (2020-01-19)
Multiple kinases converge on the transcription factor cAMP response element-binding protein (CREB) to enhance the expression of proteins essential for long-term synaptic plasticity and memory. The p90 ribosomal S6 kinase (RSK) is one of these kinases, although its role is
Irem Ozkan-Dagliyan et al.
Cell reports, 31(11), 107764-107764 (2020-06-20)
We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activity. The most potent combination, concurrent inhibition of RAF (RAFi)
B Nadratowska-Wesolowska et al.
Oncogene, 33(40), 4823-4836 (2013-10-22)
FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover novel

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