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S2442

Sigma-Aldrich

S9 from Liver, Pooled

from human

Sinónimos:

Liver S9 Fraction, S9 Liver Extract

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

biological source

human

Quality Level

100

packaging

vial of ~20 mg

UniProt accession no.

P46781

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... RPS9(6203)

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Application

Pooled S9 fractions from liver have been used for genotoxicity experiments.

Biochem/physiol Actions

The hepatic S9 pools from a variety of biological sources represent the post-mitochondrial supernatant fraction from homogenized liver. Known to be a rich source of drug metabolizing enzymes including P-450, these pools are useful in the study of xenobiotic metabolism and drug interactions.
The hepatic S9 pools from a variety of biological sources represent the post-mitochondrial supernatant fraction from homogenized liver. They are known to be a rich source of drug metabolizing enzymes including P-450. S9 pools are useful in the study of xenobiotic metabolism and drug interactions. They are used in the Ames test, which is a method that uses bacteria to test if a given chemical causes mutations in the genetic material of a given test organism.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The Ames Salmonella/microsome mutagenicity assay.
Mortelmans K and Zeiger E
Mutation Research (2000)
An improvement of the Ames test using a modified human liver S9 preparation.
Hakura A
Journal of Pharmacological and Toxicological Methods, 169-172 (2001)
Implementation of the Three Rs in the Human Hazard
Assessment of Brazilian Medicinal Plants: An Evaluation
of the Cytotoxic and Genotoxic Potentials of Dipteryx
alata Vogel
Natalia M. Esteves-Pedro
Alberta RN / Alberta Association of Registered Nurses (2011)
A conjugate of pyridine-4-aldoxime and atropine as a potential
antidote against organophosphorus compounds poisoning
Jasna Lovric
Acta Biochimica Polonica, 58(2) (2011)

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