RAB1122
Mouse EPO ELISA Kit
for cell culture supernatants, plasma, and serum samples
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Productos recomendados
species reactivity
mouse
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type plasma
sample type serum sample(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.5 pg/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Epo(13856)
General description
This ELISA antibody pair detects Mouse Erythropoietin (EPO)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Erythropoietin (EPO) is a glycoprotein hormone which is essential for the proliferation of erythropoietic progenitors to produce red blood cells (RBCs). Peritubular fibroblast in kidney cortex is the primary site for EPO production in adults, though spleen, bone marrow and liver contribute to the production. In fetus, liver is the primary site for EPO production. Additionally, EPO functions in some cytoprotective activities like, antiapoptotic, antioxidant, and anti-inflammatory responses. Hypoxia inducible factors upregulate EPO expression. EPO expression increases with decreased hemoglobin concentration in few cases of anemia. Decreased production of EPO is the cause of anemia in chronic kidney diseases. Circulating endogenous antibodies to EPO (anti-EPO) is the cause of anemia in multiple diseases like human immunodeficiency virus (HIV) infection, hepatitis C virus infection, systemic lupus erythematosus. Gain-of-function polymorphism in EPO causes familial erythrocytosis.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia
Tsiakalos A, et al.
Hepatobiliary & Pancreatic Diseases International : HBPD INT, 16(3), 289-295 (2017)
Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells
Nishimura K, et al.
Archives of Biochemistry and Biophysics, 636, 11-16 (2017)
Physiology and pharmacology of erythropoietin
Jelkmann W
Transfusion Medicine and Hemotherapy : Offizielles Organ der Deutschen Gesellschaft Fur? Transfusionsmedizin und Immunham?atologie, 40(5), 302-309 (2013)
A Gain-of-Function Mutation in EPO in Familial Erythrocytosis
Zmajkovic J, et al.
The New England Journal of Medicine, 378(10), 924-930 (2018)
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