RAB0564

Mouse Tnfsf4 / Tumor Necrosis Factor Ligand Superfamily Member 4 ELISA Kit

for serum, plasma and cell culture supernatants

• UNSPSC Code: 41116158
• NACRES: NA.84

Propiedades

• species reactivity: mouse
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable
• input: sample type serum; sample type plasma; sample type cell culture supernatant(s)
• assay range: inter-assay cv: <10%; intra-assay cv: <12%; sensitivity: 30 pg/mL
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Tnfsf4(22164)

Descripción

General description

This ELISA antibody pair detects mouse TNFSF4/OX40.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Tumor necrosis factor (TNF) superfamily member 4 (Tnfsf4) signals specifically through the OX40 receptor, which is expressed primarily on CD4⁺T cells but also on certain activated CD8⁺T cells. Tnfsf4 acts as a costimulatory signal, which is essential for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival and increases expression of regulated on activation, normal T cell expressed and secreted (RANTES) or chemokine ligand 5 (CCL5), interleukins-2 and -3 and interferon γ (IFNg). Tnfsf4 signaling plays an important role in immuno-regulatory communication and immune-tolerance. Polymorphisms in the TNFSF4 gene leads to the development of autoimmune thyroid diseases (AITDs), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Los componentes del kit también están disponibles por separado

• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
• RABSTOP3 ELISA Stop Solution (Item I)
• RABELADA ELISA 1X Assay/Sample Diluent Buffer A (Item D1)
• RABELADB ELISA 5X Assay/Sample Diluent Buffer B (Item E1)
• RABWASH4 20X Wash Buffer (Item B)

Información de seguridad

• pictograms: GHS05
• signalword: Warning
• hcodes: H290
• pcodes: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class: 8A - Combustible corrosive hazardous materials
• flash_point_f: Not applicable
• flash_point_c: Not applicable