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RAB0161

Sigma-Aldrich

Phospho-EGFR (pSer1070) ELISA Kit

for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

mouse, human, rat

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type tissue lysate
sample type cell lysate

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... EGFR(1965)

Categorías relacionadas

General description

The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.

Immunogen

EGFR (pTyr1070) synthetic phosphopeptide

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Warning

hcodes

H290,H335

Hazard Classifications

Met. Corr. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible corrosive hazardous materials

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Certificados de análisis (COA)

Lot/Batch Number

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Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations.
Han W and Lo H W
Cancer Letters, 318(2), 124-134 (2012)
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Lanzetti L, et al.
Nature, 408(6810), 374-374 (2000)
Targeting the EGFR signaling pathway in cancer therapy.
Seshacharyulu P, et al.
Expert Opinion on Therapeutic Targets, 16(1), 15-31 (2012)
EGF receptor.
Wells A
The International Journal of Biochemistry & Cell Biology, 31(6), 637-643 (1999)
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
Sanson M, et al.
Human Molecular Genetics, 20(14), 2897-2904 (2011)

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