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P8013

Sigma-Aldrich

Pargyline hydrochloride

Sinónimos:

N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride

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About This Item

Fórmula lineal:
C6H5CH2N(CH3)CH2C≡CH·HCl
Número de CAS:
306-07-0
Peso molecular:
195.69
Beilstein/REAXYS Number:
3699487
EC Number:
206-175-1
MDL number:
MFCD00012492
UNSPSC Code:
12352200
PubChem Substance ID:
24278153
NACRES:
NA.77

biological source

synthetic

assay

98% (TLC)

form

powder or crystals

mp

160-163 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].CN(CC#C)Cc1ccccc1

InChI

1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

InChI key

BCXCABRDBBWWGY-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128) , MAOB(4129)

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Application

Pargyline hydrochloride has been used:
  • as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
  • to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
  • to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.
Selective MAO-B inhibitor.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

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Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors
Ifrim DC, et al.
Clinical and Vaccine Immunology : CVI, 21(4), 534-545 (2014)
Debapriya Saha et al.
Epigenomes, 4(4) (2021-04-09)
Differential DNA methylation is characteristic of gene regulatory regions, such as enhancers, which mostly constitute low or intermediate CpG content in their DNA sequence. Consequently, quantification of changes in DNA methylation at these sites is challenging. Given that DNA methylation
An update on antidepressant toxicity: an evolution of unique toxicities to master
Liebelt EL
Clinical Pediatric Emergency Medicine, 9(1), 24-34 (2008)
Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation
Li S, et al.
Journal of Neurophysiology, 98(6), 3525-3537 (2007)
Biochemical Pathway for the Formation of Abnormal Sclerotia of Sclerotinia sclerotiorum
Huang HC and Yeung JM
Plant Pathology, 11(1), 2-2 (2002)
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Artículos

Histone Modification and Chromatin Remodeling | Epigenetics

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

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