N5163

Anti-NOTCH4 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-INT3, Anti-Notch homolog 4 (Drosophila)
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~230 kDa; antigen ~80 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: 1:100-1:200; western blot: 1:500-1:1,000
• UniProt accession no.: Q99466
• application(s): research pathology
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... NOTCH4(4855) ; mouse ... Notch4(18132) ; rat ... Notch4(406162)

Descripción

General description

NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.

Immunogen

synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.

Biochem/physiol Actions

NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)