N3040

Necrostatin-7

≥98% (HPLC), powder

• Sinónimos: 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7
• Fórmula empírica (notación de Hill): C₁₆H₁₀FN₅OS₂
• Número de CAS: 351062-08-3
• Peso molecular: 371.41
• MDL number: MFCD02334728
• UNSPSC Code: 12352202
• PubChem Substance ID: 329818601

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow to tan
• solubility: DMSO: >10 mg/mL (with warming)
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
• InChI: 1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
• InChI key: SMJGLNVGTJLIRV-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable