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N144

Sigma-Aldrich

Nitrendipine

>95%, powder

Sinónimos:

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

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About This Item

Fórmula empírica (notación de Hill):
C18H20N2O6
Número de CAS:
39562-70-4
Peso molecular:
360.36
EC Number:
254-513-1
MDL number:
MFCD00082255
UNSPSC Code:
12352200
PubChem Substance ID:
24277857
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

200

assay

>95%

form

powder

color

yellow to green

solubility

methanol: 15 mg/mL
DMSO: 17.5 mg/mL
H2O: insoluble

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC

InChI

1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

InChI key

PVHUJELLJLJGLN-UHFFFAOYSA-N

Gene Information

human ... ADORA3(140) , CACNG1(786) , KCNH1(3756) , TTR(7276)
rat ... Adora1(29290) , Adora2a(25369)

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Este artículo
HS2860FHS2860EHS2860H
TrueNorth® Cardboard Cryovial Box Cell Divider Holds 49 x 1.5-2.0 mL tubes, pk of 12

HS2860G

TrueNorth® Cardboard Cryovial Box Cell Divider

TrueNorth® Cardboard Cryovial Box Cell Divider Holds 64 x 1.5-2.0 mL tubes, pk of 12

HS2860F

TrueNorth® Cardboard Cryovial Box Cell Divider

TrueNorth® Cardboard Cryovial Box Cell Divider Holds 100 x 1.5-2.0 mL tubes, pk of 12

HS2860E

TrueNorth® Cardboard Cryovial Box Cell Divider

TrueNorth® Cardboard Cryovial Box Cell Divider Holds 81 x 1.5-2.0 mL tubes, pk of 12

HS2860H

TrueNorth® Cardboard Cryovial Box Cell Divider

manufacturer/tradename

Heathrow Scientific HS2860G

manufacturer/tradename

Heathrow Scientific HS2860F

manufacturer/tradename

Heathrow Scientific HS2860E

manufacturer/tradename

Heathrow Scientific HS2860H

feature

Holds 49 x 1.5-2.0 mL tubes

feature

Holds 64 x 1.5-2.0 mL tubes

feature

Holds 100 x 1.5-2.0 mL tubes

feature

Holds 81 x 1.5-2.0 mL tubes

packaging

pk of 12

packaging

pk of 12

packaging

pk of 12

packaging

pk of 12

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

well diam.

17.5 mm

well diam.

15 mm

well diam.

11.5 mm

well diam.

12 mm

Biochem/physiol Actions

Ca2+ channel blocker; anti-hypertensive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
028F08941
038H4745

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Dengning Xia et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 446-454 (2012-04-10)
The amorphous-to-crystalline transformation of nitrendipine was investigated using Raman spectroscopy and X-ray powder diffraction (XRPD). The nucleation and growth rate of crystalline nitrendipine in a medium containing poly (vinyl alcohol) (PVA) and polyethylene glycol (PEG 200) were quantitatively determined using
Dewei Shang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3459-3464 (2011-10-05)
A HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 μL) were injected directly onto a CAPCELL MF C(8)
Peng Quan et al.
International journal of pharmaceutics, 430(1-2), 366-371 (2012-04-26)
In this study, chitosan, a cationic polymer with positive charge, was introduced to modify the nanocrystals of nitrendipine with negative charge. The nanocrystals were prepared via precipitation-high pressure homogenization method. Then the nanocrystals were dispersed into chitosan solution, and the
Yanhua Liu et al.
Arzneimittel-Forschung, 61(12), 674-680 (2012-01-28)
A rapid, sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of nitrendipine (NTD, CAS 39562-70-4) in dog plasma. Using propranolol hydrochloride (CAS 318-98-9) as an internal standard (IS), plasma samples
Xi Zhang et al.
International journal of pharmaceutics, 431(1-2), 45-52 (2012-05-01)
A novel active and multi-dose dry powder inhaler (DPI) was developed and evaluated to deliver a small quantity (100-500 μg) of pure drug without any excipient. This dry powder inhaler utilized two compressed air flows to dispense and deliver drug
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