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N0665

Sigma-Aldrich

NDSB 211

≥98% (TLC)

Sinónimos:

3-[Dimethyl-(2-hydroxyethyl)ammonio]-1-propanesulfonate, Dimethyl(2-hydroxyethyl)(3-sulfopropyl)ammonium hydroxide inner salt, Dimethyl-2-hydroxyethylammoniumpropane sulfonate

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About This Item

Fórmula empírica (notación de Hill):
C7H17NO4S
Número de CAS:
38880-58-9
Peso molecular:
211.28
EC Number:
254-176-0
MDL number:
MFCD01320397
UNSPSC Code:
12161900
PubChem Substance ID:
329818450
NACRES:
NA.25

description

zwitterionic

assay

≥98% (TLC)

form

solid

mol wt

211.28 g/mol

technique(s)

DNA extraction: suitable

color

white

solubility

methanol: 5 mg/mL, clear, colorless

SMILES string

OCC[N+](C)(C)CCCS([O-])(=O)=O

InChI

1S/C7H17NO4S/c1-8(2,5-6-9)4-3-7-13(10,11)12/h9H,3-7H2,1-2H3

InChI key

CNXPCGBLGHKAIL-UHFFFAOYSA-N

General description

Dimethyl-2-hydroxyethylammoniumpropane sulfonate, or NDSB 211, is a nondetergent-sulfobetain. It is zwitterionic over a wide pH range, easily removed by dialysis and shows no significant absorption in the near UV range.

Application

NDSB 211 has been used in a study to assess halophilic protein stabilization by the mild solubilizing agents nondetergent sulfobetaines. It has also been used in a study to investigate an alternative strategy for crystallizing macromolecules.
Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification.

Other Notes

This product is non-micelle forming.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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L Vuillard et al.
Analytical biochemistry, 230(2), 290-294 (1995-09-20)
In this work, experiments performed on pig heart and halophilic malate dehydrogenase as well as halophilic elongation factor Tu demonstrate a protein stabilization property from the recently described mild solubilizing agents nondetergent sulfobetaines. A practical application is given by the
Searching for silver bullets: An alternative strategy for crystallizing macromolecules
McPhersona, A., et al.
Journal of Structural Biology, 156, 3887-3406 (2006)
Ivanka M Karadzic et al.
Proteomics, 5(2), 354-359 (2005-01-04)
Proteins of haloarchaea are remarkably unstable in low-ionic-strength solvents and tend to aggregate under standard two-dimensional (2-D) gel electrophoresis conditions, causing strong horizontal streaking. We have developed a new approach to generate 2-D maps of halophilic proteins which included washing

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