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MilliporeSigma

MAK184

Sigma-Aldrich

Succinate Colorimetric Assay Kit

Sufficient for 100 Colorimetric tests

Sinónimos:

Succinic Acid Assay Kit

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About This Item

EC Number:
UNSPSC Code:
12161503
NACRES:
NA.84

application(s)

cosmetics
food and beverages

detection method

colorimetric

relevant disease(s)

cardiovascular diseases; immunological diseases

storage temp.

−20°C

General description

Succinate (succinic acid) is a citric acid cycle intermediate and functions in the transport of electrons to the mitochondrial electron transport chain. It also functions in innate immune signaling and induces IL-1β production during inflammation. Succinates have been often used for the treatment of hypertension. Succinate measurements can be useful for studying its metabolic, immunological, and therapeutic activities.

Application

Succinate Colorimetric Assay Kit has been used to measure the concentration of succinate.

Suitability

Suitable for the detection of succinate in a variety of samples such as cell and tissue culture supernatants and in liquid samples such as wine.

Principle

The Succinate Colorimetric Assay Kit is a highly sensitive assay for determining succinate levels (ranging from 2-10 nmole/well) in a variety of samples. Succinate concentration is determined by a coupled enzyme reaction, which results in a colorimetric (450 nm) product proportional to the succinate present.

Solo componentes del kit

Referencia del producto
Descripción

  • Succinate Assay Buffer

  • Succinate Converter

  • Succinate Enzyme Mix

  • Succinate Substrate Mix

  • Succinate Developer

  • Succinate Standard

pictograms

Health hazardCorrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Electron Transport and Oxidative Phosphorylation
Lodish H, et al.
Molecular Cell Biology (2000)
Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.
Tretter L, et al.
Biochimica et Biophysica Acta - Bioenergetics, 1857(8), 1086-1101 (2016)
VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Li J, et al.
Nature Communications, 8(1), 1322-1322 (2017)
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.
Hainer JW and Jennifer S
Vascular Health, 3(3), 279-279 (2007)
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Shen J, et al.
JCI insight, 2(12) (2017)

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