Saltar al contenido
Merck
Todas las fotos(3)

Documentos clave

Ver Toda la documentación

M6751

Sigma-Aldrich

5-Methylcytosine hydrochloride

≥99%

Sinónimos:

4-Amino-2-hydroxy-5-methylpyrimidine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(3)

About This Item

Fórmula empírica (notación de Hill):
C5H7N3O · HCl
Número de CAS:
58366-64-6
Peso molecular:
161.59
EC Number:
261-223-9
MDL number:
MFCD11053426
UNSPSC Code:
41106305
PubChem Substance ID:
24897110
NACRES:
NA.51
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

synthetic (organic)

Quality Level

200
300

assay

≥99%

form

crystalline powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless

SMILES string

O=C1NC(N)=C(C)C=N1.[H]Cl

InChI

1S/C5H7N3O.ClH/c1-3-2-7-5(9)8-4(3)6;/h2H,1H3,(H3,6,7,8,9);1H

InChI key

ANWMULVRPAUPJT-UHFFFAOYSA-N

¿Está buscando productos similares? Visita Guía de comparación de productos

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo
QBD10246QBD10127QBD11086
Bis-dPEG®13-NHS ester

QBD10954

Bis-dPEG®13-NHS ester

Bis-dPEG®9-NHS ester

QBD10246

Bis-dPEG®9-NHS ester

Acid-dPEG®13-NHS ester

QBD10127

Acid-dPEG®13-NHS ester

m-dPEG ®13-NHS ester

QBD11086

m-dPEG ®13-NHS ester

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

assay

>90%

assay

>90%

assay

>90%

assay

>90%

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: chemical modification reagent, reagent type: cross-linking reagent
reactivity: amine reactive

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Application

5-Methylcytosine hydrochloride has been used as standard in high performance liquid chromatography (HPLC) for the estimation of global methylation rates.[1] It has also been used in high-resolution mass spectroscopic analysis.[2]
5-Methylcytosine is used in studies of DNA methylation processes (epigenetics).

Biochem/physiol Actions

5-Methylcytosine mediates gene expression, genomic imprinting and inhibition of transposable elements.[3] It is closely associated with translational fidelity and tRNA recognition.[4]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCQ6089
MKCM0760
MKCP1409
MKCM8004
MKCM0630

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
Squires JE, et al.
Nucleic Acids Research, 40(11), 5023-5033 (2012)
Absolute quantification of RNA or DNA using acid hydrolysis and mass spectrometry
Lowenthal MS, et al.
Analytical Chemistry, 6, 824-824 (2019)
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito S, et al.
Science (New York, N.Y.), 333(6047), 1300-1303 (2011)
Daniel Renciuk et al.
Nucleic acids research, 41(21), 9891-9900 (2013-08-22)
5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction, we solved five structures
Shinpei Yamaguchi et al.
Cell research, 23(3), 329-339 (2013-02-13)
Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its relationship with the generation of 5-hydroxymethylcytosine (5hmC) are not clear. Here
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico