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Key Documents

M6324

Sigma-Aldrich

MART-1 (27-35), Human

Sinónimos:

Antigen LB39-AA (27-35) (human), Antigen SK29-AA (27-35) (human), Melan-A Protein (27-35) (human), Melanoma Antigen Recognized By T-Cells 1 (27-35) (human)

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

form

lyophilized powder

Quality Level

200

color

white

solubility

water, double-distilled: soluble

storage temp.

−20°C

Amino Acid Sequence

Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

General description

The peptide represents amino acids 27-35 of MART-1 protein that is the melanoma antigen recognized by T cells. This peptide mimics the natural epitope that is presented by T cells in humans with reactivity to melanoma cells.
Melanoma-associated antigen recognized by T cells-1 (MART-1), also known as Melan-A, is encoded by the gene mapped to human chromosome 9p24.1. The encoded protein is a hydrophobic transmembrane protein. MART-1 is mainly expressed in skin and retinae melanocytes.

Biochem/physiol Actions

Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis
Guo R, et al.
International Journal of Clinical and Experimental Pathology, 7(1), 468-468 (2014)
María Marcela Barrio et al.
PloS one, 7(7), e40311-e40311 (2012-07-07)
Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells. They have been used in different clinical settings to vaccinate cancer patients. We have previously used gamma-irradiated MART-1 expressing melanoma cells as

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