M076000

Sulfur 42

• Sinónimos: Phenyl-3H-1,2,4-dithiazol-3-one
• Fórmula empírica (notación de Hill): C₈H₅NOS₂
• Número de CAS: 7047-10-1
• Peso molecular: 195.26
• MDL number: MFCD02311276
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817828
• NACRES: NA.03

Propiedades

• type: for DNA synthesis
• product line: Proligo Reagents
• assay: ≥99.0% (reversed phase HPLC)
• form: solid
• packaging: pkg of 1 g M076000-1G; 2 g of 2 g M076000-2G
• impurities: ≤0.1% water content (Karl Fischer)
• color: faintly yellow to yellow
• solubility: acetonitrile: 0.1 M, clear
• suitability: conforms to structure for H-NMR
• storage temp.: 2-8°C
• SMILES string: O=C1SSC(C2=CC=CC=C2)=N1
• InChI: 1S/C8H5NOS2/c10-8-9-7(11-12-8)6-4-2-1-3-5-6/h1-5H
• InChI key: LKDWQHQNDDNHSC-UHFFFAOYSA-N

Descripción

General description

Sulfur 42 is a sulfurization reagent.

Application

Sulfur 42 is suitable for use instead of an Oxidizer during the synthesis cycle to manufacture thioated oligonucleotides.

Features and Benefits

• Sulfur 42 is at least 4 times more reactive than Beaucage reagent or PADS
• Crystalline powder
• Odourless, no foul smell
• Solubility in ACN up to 0.28M at (+10 °C); no need to applied a co-solvent like in DCM, THF
• The solvent for the dissolution of the reagent should be dry (< 50 ppm) in order to minimize P=O impurities
• Stable in ACN solution for at least 21 days
• Recommended reaction time for the sulfurization in oligonucleotide synthesis for a 0.1M solution is 60 sec

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable