J3580

JNJ 17203212

≥98% (HPLC)

• Sinónimos: N¹-(3-Trifluoromethylpyrid-2-yl)-N⁴-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
• Fórmula empírica (notación de Hill): C₁₇H₁₅F₆N₅O
• Número de CAS: 821768-06-3
• Peso molecular: 419.32
• UNSPSC Code: 12352200

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• originator: Johnson & Johnson
• storage temp.: −20°C
• InChI: 1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
• InChI key: JFRYYGVYCWYIDQ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that does not inhibit related TRP channels such as TRPV2, TRPV4, or TRPA1. Listed in BJP with IC50= 65 nM. TRPV1 channels are activated by heat, capsaicin and the endocannabinoid anandamide. Interest in TRPV1 antagonists in the transmission and modulation of pain.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319
• pcodes: P301 + P310 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable