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H3040

Sigma-Aldrich

HER2 (676-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

ERBB2, NEU, NGL, TKR1, c-erb B2

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

9-13 nmol/min·mg

mol wt

~116 kDa

UniProt accession no.

P04626

relevant disease(s)

cancer (breast)

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ERBB2(2064)

General description

HER2 (eceptor tyrosine-protein kinase erbB-2) is a cell surface-associated glycoprotein tyrosine kinase receptor.

Biochem/physiol Actions

HER2 (receptor tyrosine-protein kinase erbB-2) is an oncogene and is up-regulated in breast cancer. Overexpression of HER2 is associated with uncontrolled cellular proliferation, resistance to apoptotic cell death and increased motility.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ali Badache et al.
Journal of mammary gland biology and neoplasia, 11(1), 13-25 (2006-09-02)
Overexpression of the ErbB2/Her2 receptor tyrosine kinase in breast cancers is associated with the most aggressive tumors. Experimental studies have revealed that ErbB2 shows many features of a therapeutic target: ErbB2 is able to confer many of the characteristics of
R M Hudziak et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(20), 7159-7163 (1987-10-01)
The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the

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