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H3038

Sigma-Aldrich

Anti-HCN1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-BCNG1, Anti-HAC2, Anti-Hyperpolarization-activated Cyclic Nucleotide-gated Potassium Channel 1

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About This Item

MDL number:
MFCD03792000
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

immunocytochemistry: 1:300 using rat dorsal ganglion primary culture
immunohistochemistry: suitable using mouse cerebellum frozen sections
western blot: 1:200-1:400 using rat brain membranes

UniProt accession no.

Q9JKB0

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Hcn1(15165)
rat ... Hcn1(84390)

Immunogen

peptide corresponding to amino acid residues 6-24 of rat HCN1. This epitope is highly homologous in mouse (18/19 residues identical) and rabbit (16/19 residues identical).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Visite la Librería de documentos

Chang-jun Li et al.
Molecular neurobiology, 50(2), 704-720 (2014-05-20)
Hyperpolarization-activated cyclic-nucleotide-gated cation nonselective (HCN) channels are involved in the pathology of nervous system diseases. HCN channels and γ-aminobutyric acid (GABA) receptors can mutually co-regulate the function of neurons in many brain areas. However, little is known about the co-regulation
Hongxia Li et al.
Clinical and experimental pharmacology & physiology, 41(9), 698-707 (2014-05-28)
The pacemaker current If conducted by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels plays a critical role in the regulation of cardiac automaticity, with If density increased in hypertrophied ventricular myocytes. Amiodarone, a highly effective anti-arrhythmic agent, blocks human HCN currents and

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