H0786

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• Sinónimos: HRG-β
• MDL number: MFCD01867052
• UNSPSC Code: 12352202
• NACRES: NA.32

Propiedades

• biological source: human
• Quality Level: 200
• recombinant: expressed in E. coli
• assay: ≥80% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• mol wt: 185 kDa
• packaging: pkg of 100 μg
• storage condition: avoid repeated freeze/thaw cycles
• UniProt accession no.: Q02297
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... NRG1(3084)

Descripción

General description

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Physical form

Solution in phosphate buffered saline containing 30% glycerol.

Analysis Note

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable