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G0544

Sigma-Aldrich

GR 103691

≥98% (HPLC), solid

Sinónimos:

4′-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide

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About This Item

Fórmula empírica (notación de Hill):
C30H35N3O3
Número de CAS:
162408-66-4
Peso molecular:
485.62
MDL number:
MFCD00936840
UNSPSC Code:
12352200
PubChem Substance ID:
24724488
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >5 mg/mL at 60 °C

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

COc1ccccc1N2CCN(CCCCNC(=O)c3ccc(cc3)-c4ccc(cc4)C(C)=O)CC2

InChI

1S/C30H35N3O3/c1-23(34)24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(35)31-17-5-6-18-32-19-21-33(22-20-32)28-7-3-4-8-29(28)36-2/h3-4,7-16H,5-6,17-22H2,1-2H3,(H,31,35)

InChI key

JARNORYOPMINDY-UHFFFAOYSA-N

Gene Information

rat ... Htr1a(24473)

Application

GR 103691 has been used as a D3 receptor antagonist to test its:
  • inducing effect on prepulse inhibition (PPI)
  • suppressive effect of motor behavior in rats
  • inhibitory effect on chemotaxis in newly excysted juvenile C. sinensis (CsNEJs)

Biochem/physiol Actions

D3 dopamine receptor antagonist.
GR 103691 increases the monosynaptic “stretch” reflex (MSR) amplitude in mice by its potent D3 receptor antagonist functionality. It inhibits the PD 128,907 mediated γ-aminobutyric acid (GABA) release.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
089K4614V
089K4614
053K4608
034K4604

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Roberto Frau et al.
Psychoneuroendocrinology, 63, 59-67 (2015-09-29)
Neurosteroids exert diverse modulatory actions on dopamine neurotransmission and signaling. We previously documented that the enzyme 5α-reductase, which catalyzes the main rate-limiting step in neurosteroid synthesis, is required for the behavioral responses of Sprague-Dawley rats to non-selective dopaminergic agonists, such
Refugio Cruz-Trujillo et al.
Neuropharmacology, 67, 370-378 (2012-12-15)
The firing rate of substantia nigra reticulata (SNr) neurons is modulated by GABA release from striatonigral and pallidonigral projections. This release is, in turn, modulated by dopamine acting on dopamine D1 receptors at striatonigral terminals and D4 receptors at pallidonigral
Shunyu Li et al.
PLoS neglected tropical diseases, 13(8), e0007573-e0007573 (2019-08-14)
The metacercariae of the Clonorchis sinensis liver fluke excyst in the duodenum of mammalian hosts, and the newly excysted juveniles (CsNEJs) migrate along the bile duct via bile chemotaxis. Cholic acid is a major component of bile that induces this

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