E5139
DL-Ethionine
≥95% (TLC)
Sinónimos:
DL-2-Amino-4-(ethylthio)butyric acid
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About This Item
Fórmula lineal:
C2H5SCH2CH2CH(NH2)COOH
Número de CAS:
Peso molecular:
163.24
Beilstein/REAXYS Number:
1722529
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
Productos recomendados
Nombre del producto
DL-Ethionine, ≥95% (TLC)
assay
≥95% (TLC)
form
powder
color
white to off-white
mp
269 °C
application(s)
cell analysis
storage temp.
−20°C
SMILES string
CCSCCC(N)C(O)=O
InChI
1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)
InChI key
GGLZPLKKBSSKCX-UHFFFAOYSA-N
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Application
- Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration.: This study evaluates the hepatic oxidative stress in cattle induced by ethionine administration by measuring superoxide dismutase activity. The findings suggest a significant oxidative response, highlighting the role of DL-Ethionine in studying liver oxidative mechanisms (Abd Ellah et al., 2009).
Biochem/physiol Actions
DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Muneyoshi Kanai et al.
Journal of bioscience and bioengineering, 123(1), 8-14 (2016-08-28)
Sake yeasts are ideally suited for sake making, producing higher levels of ethanol, proliferating at lower temperatures, and producing greater levels of various aromatic components and nutrients than laboratory yeasts. To elucidate the mechanism underlying S-adenosylmethionine (SAM) accumulation in sake
Sabrina C Wentz et al.
The Journal of surgical research, 157(1), e87-e95 (2009-07-01)
Intrahepatic cholangiocarcinoma (ICC) incidence and mortality are increasing in the United States and worldwide. ICC etiologies involve chronic inflammation. We hypothesize that the nonsteroidal anti-inflammatory agent sulindac may prevent ICC by targeting cyclooxygenase-1 and -2 (COX-1, -2) as well as
Yingying Liu et al.
Stem cells (Dayton, Ohio), 33(12), 3569-3580 (2015-06-03)
Upregulation of osteopontin (OPN) has been found in hepatic progenitor cells (HPCs) in several liver diseases with portal biliary proliferation. Here, we investigated the role of HPC-derived autocrine OPN in regulating HPC expansion, migration, and hepatocarcinogenesis in mice. Five-week-old, weighing
Janeli Viil et al.
Scientific reports, 7, 40322-40322 (2017-01-14)
Cells with slow proliferation kinetics that retain the nuclear label over long time periods-the label-retaining cells (LRCs)-represent multipotent stem cells in a number of adult tissues. Since the identity of liver LRCs (LLRCs) had remained elusive we utilized a genetic
Mahmoud R Abd Ellah et al.
Veterinary journal (London, England : 1997), 182(2), 336-341 (2008-07-01)
The goal of this study was to assess if oxidative stress, as measured by alterations in the concentrations of antioxidant enzymes in the liver and erythrocytes of cattle, could be induced following dl-ethionine administration. Whole blood, serum and liver biopsy
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