E0407

Estramustine sodium phosphate

• Sinónimos: Estra-1,3,5(10)triene-3,17ß-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt, Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt
• Fórmula empírica (notación de Hill): C₂₃H₃₀Cl₂NNa₂O₆P
• Número de CAS: 52205-73-9
• Peso molecular: 564.35
• EC Number: 257-735-7
• MDL number: MFCD00866320
• UNSPSC Code: 51111800
• PubChem Substance ID: 329798968
• NACRES: NA.28

Propiedades

• assay: ≥85.0% (HPLC)
• form: powder
• solubility: H₂O: 50 mg/mL
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@]12[C@@]([C@@](CC[C@@H]3OP([O-])([O-])=O)([H])[C@]3(C)CC2)([H])CCC4=C1C=CC(OC(N(CCCl)CCCl)=O)=C4.[Na+].[Na+]
• InChI: 1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1
• InChI key: IIUMCNJTGSMNRO-VVSKJQCTSA-L
• Gene Information: human ... ESR2(2100)

Descripción

Biochem/physiol Actions

Estradiol mustard prodrug, which binds estradiol receptors irreversibly. Highly effective in treatment of advanced metastatic prostate cancer. Depolymerizes microtubules by binding to microtubule associated proteins (MAPs).

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves