D5314
DPQ
≥98% (HPLC), solid
Sinónimos:
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone
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About This Item
Fórmula empírica (notación de Hill):
C18H26N2O2
Número de CAS:
Peso molecular:
302.41
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Productos recomendados
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
solid
mp
107-109 °C
solubility
DMSO: 1 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI key
RVOUDNBEIXGHJY-UHFFFAOYSA-N
Application
DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.
Biochem/physiol Actions
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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