D4321

Dihydroeponemycin

≥98% (HPLC)

• Fórmula empírica (notación de Hill): C₂₀H₃₆N₂O₆
• Número de CAS: 126463-64-7
• Peso molecular: 400.51
• MDL number: MFCD17215971
• UNSPSC Code: 12352202
• PubChem Substance ID: 329798798
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D ±35.7°
• color: off-white to light tan
• solubility: DMSO: ≥1 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(C)CCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO)CO1
• InChI: 1S/C20H36N2O6/c1-13(2)7-5-6-8-17(25)21-16(10-23)19(27)22-15(9-14(3)4)18(26)20(11-24)12-28-20/h13-16,23-24H,5-12H2,1-4H3,(H,21,25)(H,22,27)/t15-,16-,20+/m0/s1
• InChI key: IUDBVFIQSSOIDB-TWOQFEAHSA-N

Descripción

Biochem/physiol Actions

Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable