Saltar al contenido
MilliporeSigma
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

D3938

Sigma-Aldrich

Anti-DR5 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Death Receptor 5, Anti-KILLER, Anti-TRAIL-R2, Anti-TRICK2

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

MDL number:
MFCD01865566
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 57 kDa

species reactivity

human

technique(s)

microarray: suitable
western blot: 2 μg/mL using human HeLa and K562 cell extracts

UniProt accession no.

O14763

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TNFRSF10B(8795)

General description

DR5 is a death domain-containing receptor that is activated through a p53-depedent pathway in response to radiation and DNA damage . DR5 is involved in caspase activation and cell apoptosis . Anti-DR5 antibody is specific for DR5 in humans.

Immunogen

synthetic peptide corresponding to amino acids 388-407 of the human DR5 precursor.

Application

Anti-DR5 antibody may be used in western blot (1 μg/mL using human HeLa and K562 cell extracts), immunoblot and microarray.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Optional

Referencia del producto
Descripción
Precios

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

R Takimoto et al.
Oncogene, 19(14), 1735-1743 (2000-04-25)
KILLER/DR5, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor gene, has been shown to be induced by DNA damaging agents and radiation in a p53-dependent manner. Although TRAIL is a potential therapeutic agent for cancer, the induction mechanism of
G S Wu et al.
Oncogene, 18(47), 6411-6418 (1999-12-22)
The TRAIL death receptor KILLER/DR5 is induced by DNA damaging agents in wild-type p53-expressing cells. Here we show that, unlike the p53-target CDK-inhibitor p21WAF1/CIP1, the TRAIL death receptor KILLER/DR5 is only induced in cells undergoing p53-dependent apoptosis and not cell
Giovanni Migliaccio et al.
Blood cells, molecules & diseases, 47(3), 182-197 (2011-07-22)
The number of erythroblasts generated ex-vivo under human-erythroid massive-amplification conditions by mononuclear cells from one unit of adult blood (~10(10)) are insufficient for transfusion (~10(12) red cells), emphasizing the need for studies to characterize cellular interactions during culture to increase
Alan D Brooks et al.
Molecular cancer research : MCR, 8(5), 729-738 (2010-05-06)
Bortezomib (VELCADE) could sensitize certain human renal cell carcinoma (RCC) lines to the apoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Analysis of seven human RCC showed a clear increase in the sensitivity of four of the RCC to
Henning Walczak et al.
Methods in molecular biology (Clifton, N.J.), 414, 221-239 (2008-01-08)
The extrinsic apoptosis pathway is activated when certain members of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) are oligomerized by their cognate ligands that are members of the TNF superfamily (TNFSF). The apoptosis-inducing capacity of a member of the
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico