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D3630

Sigma-Aldrich

Diphenhydramine hydrochloride

≥98% (HPLC)

Sinónimos:

2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C17H21NO · HCl
Número de CAS:
147-24-0
Peso molecular:
291.82
EC Number:
205-687-2
MDL number:
MFCD00012479
UNSPSC Code:
12352116
PubChem Substance ID:
24277771
NACRES:
NA.77

Quality Level

200

assay

≥98% (HPLC)

form

powder

originator

Johnson & Johnson

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Application

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies

Biochem/physiol Actions

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

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Simultaneous determination of pseudoephedrine hydrochloride and diphenhydramine hydrochloride in cough syrup by gas chromatography (GC)
Raj SV, et al.
Talanta, 46(1), 221-225 (1998)
Clinical evaluation of diphenhydramine hydrochloride for the treatment of insomnia in psychiatric patients: a double-blind study
Kudo Y and Kurihara M
Journal of Clinical Pharmacology, 30(11), 1041-1048 (1990)
Reevaluation of the embryonic stem cell test
Inselman AL, et al.
International journal of regulatory science, 1(1), 32-49 (2013)
Pharmacologic characterization of AMG8379, a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV1. 7
Kornecook TJ, et al.
Journal of Pharmacology and Experimental Therapeutics, 362(1), 146-160 (2017)
R U Agu et al.
Pharmaceutical research, 16(9), 1380-1385 (1999-09-25)
To test two in vitro human nasal epithelial cell culture systems for their ability to screen the effects of pharmaceutical compounds on ciliary beating. Human nasal epithelial cells were cultured as monolayer and in a sequential monolayer-suspension culture with in
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