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C1355

Sigma-Aldrich

Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate

≥90%

Sinónimos:

Z-LEHD-FMK, Z-LE(OMe)HD(OMe)-FMK

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About This Item

Fórmula empírica (notación de Hill):
C32H43FN6O10 · xC2HF3O2 · yH2O
Número de CAS:
210345-04-3
Peso molecular:
690.72 (anhydrous free base basis)
MDL number:
MFCD01862609
UNSPSC Code:
12352200
PubChem Substance ID:
329774878

assay

≥90%

form

film

storage condition

desiccated

color

colorless to light brown

solubility

DMSO: 10 mg/mL, clear

shipped in

dry ice

storage temp.

−20°C

SMILES string

COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

InChI

1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)/t22-,23-,24-,25-/m0/s1

InChI key

YXRKBEPGVHOXSV-QORCZRPOSA-N

Application

A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Maegan L Askew et al.
Frontiers in systems neuroscience, 9, 91-91 (2015-07-01)
This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-β-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the α subtype of estrogen receptor (ERα), catecholamines
Melissa García-Caballero et al.
Frontiers in pharmacology, 8, 802-802 (2017-11-23)
Evasion of apoptosis is a hallmark of cancer especially relevant in the development and the appearance of leukemia drug resistance mechanisms. The development of new drugs that could trigger apoptosis in aggressive hematological malignancies, such as AML and CML, may
Zheng-Zhi Zou et al.
Oncotarget, 8(14), 22414-22432 (2015-10-16)
Here, we showed the antibiotic salinomycin (SAL) combined with GEF exerted synergistic cytotoxicity effects in colorectal cancer cells irrespective of their EGFR and KRAS status, with a relatively low toxicity to normal cells. Additionally, combination of the two drugs overcame
Georg Bauer
Mechanisms of ageing and development, 172, 59-77 (2017-11-16)
Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. of tumor cells with high concentrations of H2O2, peroxnitrite, HOCl, or increasing the
Walter R Lopes de Campos et al.
PloS one, 9(10), e110930-e110930 (2014-10-21)
HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART). For these reasons, we investigated the direct and indirect effects of HIV-1
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