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MilliporeSigma

C0279

Sigma-Aldrich

Carboxypeptidase Inhibitor from potato tuber

lyophilized powder

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About This Item

Número de CAS:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

plant (white russett potato)

form

lyophilized powder

potency

1.1-6.0 nM Ki [CPB]
1.5-3.5 nM Ki [CPA]

mol wt

apparent mol wt 4.075-4.333 kDa

composition

Protein, ≥35% Lowry

solubility

water: soluble 5 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

Broad-spectrum inhibitor of carboxypeptidases of animal digestive-tract origin, but little or no activity against plant and microbial carboxypeptidases. However, recent results suggest it may play a part in resistance to microbial pathogens by preventing digestion of protein.

Packaging

Package size based on protein content

Unit Definition

One μg of inhibitor protein will inhibit the activity of ≥3 μg of carboxypeptidase A by 50% using hippuryl-L-phenylalanine as substrate at pH 7.5 at 25°C.

Physical form

Lyophilized powder containing traces of sodium citrate and sodium chloride; balance primarily non-protein components.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Jarosław Króliczewski et al.
Scientific reports, 6, 34557-34557 (2016-10-05)
The cytochrome b
Purification and properties of a carboxypeptidase inhibitor from potatoes.
C A Ryan et al.
The Journal of biological chemistry, 249(17), 5495-5499 (1974-09-10)
David Thompson et al.
The Journal of biological chemistry, 284(37), 24891-24903 (2009-07-11)
We have identified, purified, and characterized three subcomplexes of PA700, the 19 S regulatory complex of the 26 S proteasome. These subcomplexes (denoted PS-1, PS-2, and PS-3) collectively account for all subunits present in purified PA700 but contain no overlapping

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