A8404

Amitriptyline hydrochloride

≥98% (TLC), powder

• Fórmula empírica (notación de Hill): C₂₀H₂₃N · HCl
• Número de CAS: 549-18-8
• Peso molecular: 313.86
• EC Number: 208-964-6
• MDL number: MFCD00012537
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278073
• NACRES: NA.77

Propiedades

• assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• solubility: H₂O: soluble; ethanol: soluble
• originator: Bristol-Myers Squibb
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , SLC6A2(6530) , SLC6A4(6532)

Descripción

Application

Amitriptyline hydrochloride has been used:

• as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
• as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
• as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse

Biochem/physiol Actions

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Features and Benefits

Shelf-life of the powder is at least three years.

Información de seguridad

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301,H319,H361d,H410
• pcodes: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges