A6655
Aflatoxin B1−BSA Conjugate from Aspergillus flavus
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General description
Aflatoxin B1 is the most toxic aflatoxin. Aflatoxins are hepatotoxic metabolites, that are produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins contaminate human food and animal feed. They are linked to liver cancer, immune system suppression, reduced growth rates, losses in feed efficiency and death. They are naturally found toxic carcinogens and the most widely known mycotoxins. They mainly contaminate fruits, vegetables and grains.
Application
Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene.
Aflatoxin B1-BSA Conjugate from Aspergillus flavus has been used in immunization of mice with phage and synthetic peptide. It is also used as a target molecule in si field-effect transistor (FET) biosensing techniques.
Warning
Possibly carcinogenic.
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Danger
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B
Storage Class
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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P Sizaret et al.
Journal of immunological methods, 63(2), 159-162 (1983-10-14)
We reported previously on the properties of an anti-aflatoxin B1 (AFB) antiserum raised with a conjugate in which AFB is coupled at the C8 position to bovine serum albumin (BSA). The hapten/carrier protein molar ratio of the conjugate was 14.
P Sizaret et al.
Journal of the National Cancer Institute, 69(6), 1375-1381 (1982-12-01)
Rabbit (outbred albino New Zealand White) antisera have been raised against aflatoxin B1 (AFB1) using as immunogen conjugates in which the hapten was coupled to bovine serum albumin (BSA) either through C1 or C8 with the oxime and the dichloride
Review of past and present research on Aflatoxin in Uganda
Kaaya NA and Warren HL
African Journal of Food, Agriculture, Nutrition and Development, 5(1), 425-428 (2005)
Physicochemical and immunological characterization of chitosan-coated bacteriophage nanoparticles for in vivo mycotoxin modeling
de Andrade CYT, et al.
Carbohydrate Polymers, 185(4), 63-72 (2018)
Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens (2008)
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