A4980
Abz-FRK(Dnp)P-OH trifluoroacetate salt
≥95% (HPLC), film
Sinónimos:
o-Aminobenzoic acid-FRK(Dnp)P-OH, o-aminobenzoic acid-Phe-Arg-Lys(DNP)-Pro-OH trifluoroacetate salt, Abz-Phe-Arg-Lys(DNP)-Pro-OH
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About This Item
Fórmula empírica (notación de Hill):
C39H49N11O10 · xC2HF3O2
Peso molecular:
831.87 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
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Amino Acid Sequence
Abz-Phe-Arg-Lys-DNP-Pro
Application
Abz-FRK(Dnp)P-OH trifluoroacetate (TFA) is a substrate for the Angiotensin Converting Enzyme (ACE). Abz-FRK(Dnp)P-OH TFA has been used to study both the reduction of mortality of patients with sepsis and paracetamol-induced hypothermia.
Biochem/physiol Actions
Substrate for ACE (Angiotensin Converting Enzyme). Internally quenched fluorogenic substrate for Real Time Fluorescent Assay.
Features and Benefits
This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jérémie Neasta et al.
British journal of pharmacology, 173(8), 1314-1328 (2016-03-31)
Using an in-house bioinformatics programme, we identified and synthesized a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Here, we have studied its biological activity, in vitro and in vivo, and have identified its target in the brain. The affinity of the peptide was characterized
Maria Fernanda de M Costa et al.
Journal of veterinary science, 12(1), 21-25 (2011-03-04)
Angiotensin-I converting enzyme (ACE) is a key regulator of blood pressure, electrolytes and fluid homeostasis through conversion of angiotensin I into angiotensin II. Recently, a genetic polymorphism of the ACE gene, which accounts for 47% of the variation of ACE
Arnau Hervera et al.
Molecular pain, 7, 25-25 (2011-04-14)
The local administration of μ-opioid receptor (MOR) agonists attenuates neuropathic pain but the precise mechanism implicated in this effect is not completely elucidated. We investigated if nitric oxide synthesized by neuronal (NOS1) or inducible (NOS2) nitric oxide synthases could modulate
Samir S Ayoub et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(9), 1689-1695 (2011-06-02)
In recent years, there has been increasing interest in hypothermia induced by paracetamol for therapeutic purposes, which, in some instances, has been reported as a side effect. Understanding the mechanism by which paracetamol induces hypothermia is therefore an important question.
Wen Yang et al.
The Journal of pharmacology and experimental therapeutics, 339(3), 832-841 (2011-08-30)
Treatment with statins, inhibitors of HMG-CoA reductase, extends the survival of septic mice. However, the molecular mechanisms underlying the cholesterol-lowering, independent beneficial effects of statins in sepsis are poorly understood. The inhibition of protein isoprenylation, namely farnesylation and geranylgeranylation, has
Artículos
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