A1887

Albúmina from human serum

lyophilized powder, essentially fatty acid free

• Sinónimos: HSA
• Número de CAS: 70024-90-7
• EC Number: 274-272-6
• MDL number: MFCD00081418
• UNSPSC Code: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

Propiedades

• biological source: human
• Quality Level: 300
• assay: ≥96% (agarose gel electrophoresis)
• form: lyophilized powder
• mol wt: monomer calculated mol wt 66478 Da
• technique(s): ELISA: suitable; tissue culture: suitable; western blot: suitable
• impurities: HIV I and HIVII, HCV and HBsAg, tested negative; ≤0.007% Fatty Acids
• solubility: H₂O: soluble 50 mg/mL, clear to slightly hazy
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Descripción

General description

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.

Application

Albumin from human serum has been used:

• as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
• to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
• to study its effect on wound healing process

Biochem/physiol Actions

La seroalbúmina funciona como una proteína transportadora para esteroides, ácidos grasos y hormonas tiroideas, y es vital en la regulación de las presiones osmóticas coloidales de la sangre. También se ha observado que la albúmina se une a sustancias exógenas, en particular medicamentos (ibuprofeno, warfarina) y que influye fuertemente en su farmacocinética. El estrés oxidativo que induce cambios en el estado rédox de la albúmina tiene efectos muy variados sobre su función fisiológica.

Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.

Preparation Note

Prepared from albumin (A1653)

Other Notes

Encontrará más información en seroalbúmina humana.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves