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90C2

Sigma-Aldrich

Leukocyte Naphthol AS-D Chloroacetate (Specific Esterase) Kit

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Leder Stain

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About This Item

UNSPSC Code:
12352106
NACRES:
NA.47

description

Select reagents packaged in gelatin capsules

Quality Level

500

shelf life

Expiry date on the label.

IVD

for in vitro diagnostic use

dilution

(for histology)

application(s)

hematology
histology

shipped in

wet ice

storage temp.

2-8°C

Application

Esterases are ubiquitous in nature and encompass a series of different enzymes acting upon select substrates. With the 90C2 kit, Naphthol AS-D Chloroacetate is enzymatically hydrolyzed by "specific esterase, " liberating a free naphthol compound. This then couples with a diazonium salt, forming highly colored deposits at sites of enzyme activity. This enzyme is usually considered specific for cells of granulocytic lineage. May be used to detect neutrophils in peripheral blood, bone marrow or tissue sections which have been paraffin embedded.

Solo componentes del kit

Referencia del producto
Descripción
  • Dimethyl formamide (9010) 25 mL
  • Fast Corinth V Salt (9015) 10 capsules

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS
  • 2852Acid Hematoxylin Solution 100 mLSDS
  • 905Naphthol AS-D Chloroacetate 10 x 20SDS
  • 903CTRIZMAL™ 6.3 Buffer Concentrate, pH 6.3(concentrate), 0.2 M 50 mLSDS

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1B

supp_hazards

EUH044

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SLBT1859
SLBQ8658V
SLBL7093V
SLBL0288
SLBL0289

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Feng Dong et al.
Circulation research, 106(3), 601-610 (2009-12-26)
Hypoxia inducible factor (HIF)-1alpha is a transcription factor stabilized by hypoxia. It regulates cytokines involved in the inflammatory response after ischemia and affects white blood cell (WBCs) function. The effect of HIF-1alpha on WBC function and inflammation following myocardial infarction
J Heijmans et al.
Oncogene, 32(9), 1202-1206 (2012-04-04)
Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation
John Zagorski et al.
Journal of immunology (Baltimore, Md. : 1950), 179(11), 7820-7826 (2007-11-21)
Right ventricular (RV) dysfunction is a strong risk factor for poor clinical outcome following pulmonary embolism (PE), the third most prevalent cardiovascular disease. Previous studies in our laboratory demonstrated that RV failure during PE is mediated, in part, by neutrophil-dependant
Chengjie Ma et al.
Molecular medicine reports, 22(1), 483-493 (2020-04-23)
Inactivation of the Hippo pathway protects the myocardium from cardiac ischemic injury. MicroRNAs (miRs) have been reported to play pivotal roles in the progression of myocardial infarction (MI). The present study examined whether miR‑93 could promote angiogenesis and attenuate remodeling

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