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69554

Sigma-Aldrich

Peptidoglycan from Bacillus subtilis

Sinónimos:

PGN

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About This Item

MDL number:
MFCD00212486
UNSPSC Code:
41116134
NACRES:
NA.21

form

solid

Quality Level

100

storage temp.

−20°C

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General description

Peptidoglycan.is a biopolymer that is a major component of the cell walls of Gram-positive bacteria. Peptidoglycan consists of a carbohydrate backbone of alternating units of N-acetyl glucosamine and N-acetyl muramic acid and is modified with both D- and L-amino acids. N-Acetyl muramic acid residues are cross-linked with oligopeptides. The terminal peptide is D-alanine although other amino acids are present as D-isomers.

Application

Peptidoglycan may be used for the activity estimation of lytic enzymes (e.g. lyticase). It is recommended to use a peptidoglycan concentration of 0.15-3 μg/ml in water or buffer and measuring at 450 nm. The peptidoglycan is not soluble but produces a suspension in water.
Peptidoglycan activates the Toll-like receptor 2 (TLR2), present in mammalian cells for the stimulation of lymphocytes. It may also function as an antagonist of Poly (I:C).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Angela Cuttitta et al.
Fish & shellfish immunology, 67, 86-94 (2017-06-06)
Gene family encoding allograft inflammatory factor-1 (AIF-1) is well conserved among organisms; however, there is limited knowledge in lower organisms. In this study, the first AIF-1 homologue from cnidarians was identified and characterised in the sea anemone Anemonia viridis. The
Yichao Xie et al.
Fish & shellfish immunology, 106, 384-392 (2020-08-11)
Antimicrobial peptide (AMP) is a crucial component of the innate immune system in crustaceans. In mud crab, Scylla paramamosain, a commercially important species, a glycine-rich antimicrobial peptide (Spgly-AMP) gene was newly identified and putatively encoded a 26aa signal peptide and
Christian Stelter et al.
PloS one, 6(6), e20749-e20749 (2011-06-23)
Intestinal inflammation induces alterations of the gut microbiota and promotes overgrowth of the enteric pathogen Salmonella enterica by largely unknown mechanisms. Here, we identified a host factor involved in this process. Specifically, the C-type lectin RegIIIβ is strongly upregulated during
Qian Zhu et al.
Fish & shellfish immunology, 100, 9-17 (2020-03-05)
Interleukin (IL)-11 is a multifunctional cytokine that exerts a series of important immunomodulatory effects and exists in many tissues and cells. A 1106-bp nucleotide sequence representing the complete cDNA of IL-11 was obtained from large yellow croaker (Larimichthys crocea), containing
Yu-Yuan Chen et al.
PloS one, 9(12), e115232-e115232 (2014-12-18)
Invertebrates rely on an innate immune system to combat invading pathogens. The system is initiated in the presence of cell wall components from microbes like lipopolysaccharide (LPS), β-1,3-glucan (βG) and peptidoglycan (PG), altogether known as pathogen-associated molecular patterns (PAMPs), via
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Artículos

Peptidoglycan Structure, Biosynthesis and Function

The basic structure of peptidoglycan (PGN) contains a carbohydrate backbone of alternating units of N-acetylglucosamine (GlcNAc) and Nacetylmuramic acid, with the N-acetylmuramic acid residues cross-linked to peptides.

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